The biochemistry, measurement and current clinical significance of asymmetric dimethylarginine

被引:62
作者
Blackwell, Scott [1 ]
机构
[1] Glasgow Royal Infirm, Dept Clin Biochem, Glasgow G4 0SF, Lanark, Scotland
关键词
NITRIC-OXIDE SYNTHASE; TYPE-2; DIABETES-MELLITUS; CORONARY-ARTERY-DISEASE; CHROMATOGRAPHY-MASS SPECTROMETRY; CRITICALLY-ILL PATIENTS; CHRONIC KIDNEY-DISEASE; PERFORMANCE LIQUID-CHROMATOGRAPHY; INDUCED ENDOTHELIAL DYSFUNCTION; ADVERSE CARDIOVASCULAR EVENTS; CONVERTING ENZYME-INHIBITION;
D O I
10.1258/acb.2009.009196
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Asymmetric dimethylarginine (ADMA) is an endogenous competitive inhibitor of nitric oxide synthase and an important cause of endothelial dysfunction. Its increased plasma concentration is associated with a variety of traditional cardiovascular risk factors, and may mediate their effects on the vascular endothelium. ADMA is also an independent predictor of cardiovascular events and mortality, and predicts outcomes in critically ill patients in the intensive care unit. This work has provided insights into the role of ADMA as an endogenous regulator of nitric oxide synthesis. At present there is no specific therapy to modify ADMA concentration, but increasing interest and work on protein arginine methyltransferases and dimethylarginine dimethylaminohydrolase, which synthesize and metabolize ADMA, respectively, might provide novel therapeutic targets.
引用
收藏
页码:17 / 28
页数:12
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