Anti-inflammatory drug therapy in asthma

被引：21

作者：

Rottier, Bart L. ^{[1
]}

Duiverman, Eric J. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Paediat Pulmonol & Allergy, NL-9700 RB Groningen, Netherlands

来源：

PAEDIATRIC RESPIRATORY REVIEWS | 2009年 / 10卷 / 04期

关键词：

asthma; preschool wheeze; inhaled corticosteroids; cromones; macrolides; leukotriene receptor antagonists; theophylline; INHALED CORTICOSTEROIDS; PRESCHOOL-CHILDREN; LUNG-FUNCTION; RESPIRATORY SYMPTOMS; CLINICAL REMISSION; CIGARETTE-SMOKING; MONTELUKAST; FLUTICASONE; BUDESONIDE; ALLERGY;

D O I：

10.1016/j.prrv.2009.06.007

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Asthma is a disease with chronic inflammation of the airways and and-inflammatory treatment is a logical treatment. Inhaled corticosteroids [ICS] remain the cornerstone of anti-inflammatory therapy in recent international guidelines. Asthma cannot be cured by any medication: if the drug is discontinued, the disease manifestations return. This has been proven at all ages. In preschool children the diagnosis of asthma is difficult to establish. In this heterogeneous group ICS or leukotriene receptor antagonists [LTRA] are just as effective as placebo; in the future it will hopefully be possible to describe characteristics of responders. LTRA are an alternative in mild asthma, especially when mono-triggered viral related wheeze is present. Theophylline is effective and also has bronchodilatory properties, which need to be balanced against the relatively frequent side effects. The working mechanisms of anti-inflammatory asthma medications including ICS, LTRA, cromones, macrolides and theophylline are described. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：214 / 219

页数：6

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