Fluorescence in situ hybridization assessment of the telomeric regions of jumping translocations in a case of aggressive B-cell non-Hodgkin lymphoma

被引：32

作者：

Gray, BA ^{[1
]}

BentWilliams, A ^{[1
]}

Wadsworth, J ^{[1
]}

Maiese, RL ^{[1
]}

Bhatia, A ^{[1
]}

Zori, RT ^{[1
]}

机构：

[1] UNIV FLORIDA,COLL MED,DEPT PATHOL,UFHSC,GAINESVILLE,FL 32610

来源：

CANCER GENETICS AND CYTOGENETICS | 1997年 / 98卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(96)00409-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report a jumping translocation involving a donor chromosome 1 long arm in a case of aggressive B-cell non-Hodgkin lymphoma (NHL). Conventional cytogenetic banding studies demonstrated a breakpoint distal to the heterochromatic region of the donor 1q chromosome. Characterization by fluorescence in situ hybridization (FISH) of the jumping translocation demonstrated an apparent telomeric sequence loss of the recipient chromosomes. Additional cytogenetic aberrations, including the t(18;22) translocation associated with non-Hodgkin lymphoma, were also observed in this case. Cytogenetically similar cases of jumping translocations reported in the literature have implicated a preferential involvement of the donor chromosomes' heterochromatic regions and the telomeric regions of the recipient chromosomes. Pumping translocations are still considered rare and their appearance is associated with a poor prognosis. The presence of these specific findings for this case are discussed and compared with those previously reported in other hematologic disorders. (C) Elsevier Science Inc., 1997.

引用

页码：20 / 27

页数：8

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