A Multi-channel platform for recording and stimulation of large neuronal structures

被引：6

作者：

Guillemaud, R. ^{[1
]}

Beche, J. -F. ^{[1
]}

Billoint, O. ^{[1
]}

Bonnet, S. ^{[1
]}

Gharbi, S. ^{[1
]}

Rostaing, J. -P. ^{[1
]}

Trevisiol, M. ^{[1
]}

Yvert, B. ^{[2
]}

Rousseau, L. ^{[3
]}

Goy, F. ^{[4
]}

Heuschkel, M. ^{[5
]}

David, O. ^{[6
]}

Saillet, S. ^{[6
]}

Charvet, G. ^{[1
]}

机构：

[1] CEA LETI Minatec, F-38047 Grenoble, France

[2] CNRS, CNIC, F-33405 Talence, France

[3] ESIEE, F-93162 Noisy Le Grand, France

[4] BioLog SAS, F-38640 Claix, France

[5] Ayanda Biosyst SA, Lausanne, Switzerland

[6] GIN, Inserm U836, F-38700 La Tronche, France

来源：

IRBM | 2009年 / 30卷 / 5-6期

关键词：

Electrophysiology; MEA; Recording; Stimulation; ASIC; ARRAY;

D O I：

10.1016/j.irbm.2009.10.011

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In order to understand the dynamics of large neural networks, where information is widely distributed over thousands of cells, one of today's challenges is to successfully record the simultaneous activities of as many neurons as possible. This is made possible by using microelectrodes arrays (MEA) positioned in contact with the neural tissue. Thanks to microelectronics' microfabrication technologies, it now becomes,possible to build high-density MEA containing several hundreds of microelectrodes. However, increasing the number of electrodes using conventional electronics is difficult to achieve. Moreover, high-density devices addressing all channels independently for simultaneous recording and stimulation are not readily available. Here, we present a 256-channel in vitro MEA data acquisition system with integrated electronics allowing simultaneous recording and stimulation of neural networks for in vitro and in vivo applications. This integration is a first step towards an implantable device for a neural prosthesis. (C) 2009 Elsevier Masson SAS. All rights reserved,

引用

页码：226 / 233

页数：8

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