Antibacterial activity of chitosan tripolyphosphate nanoparticles loaded with various metal ions

被引：443

作者：

Du, Wen-Li ^{[1
]}

Niu, Shan-Shan ^{[2
]}

Xu, Ying-Lei ^{[1
]}

Xu, Zi-Rong ^{[1
]}

Fan, Cheng-Li ^{[1
]}

机构：

[1] Zhejiang Univ, Minist Educ, Key Lab Mol Anim Nutr, Coll Anim Sci,Inst Feed Sci, Hangzhou 310029, Zhejiang, Peoples R China

[2] Zhejiang Univ, Dept Hort, State Agr Minist Lab Hort Plant Growth Dev & Biot, Lab Fruit Mol Physiol & Biotechnol, Hangzhou 310029, Zhejiang, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2009年 / 75卷 / 03期

关键词：

Chitosan nanoparticles; Antibacterial activity; Particle size; Zeta potential; CROSS-LINKED CHITOSAN; ANTIMICROBIAL ACTIVITY; DELIVERY; ADSORPTION; BEHAVIOR; CARRIERS; SYSTEMS; SURFACE;

D O I：

10.1016/j.carbpol.2008.07.039

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The aim of this study was to prepare and select chitosan nanoparticles loaded metal ions with high antibacterial activities. Chitosan nanoparticles were prepared based on ionic gelation between chitosan and sodium tripolyphosphate. Then, Ag+, Cu2+, Zn2+, Mn2+, or Fe2+ Was individually loaded onto chitosan nanoparticles. Their particle sizes and zeta potentials were measured. Their antibacterial activities were evaluated by determination of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Escherichia coli 25922, Salmonella choleraesuis ATCC 50020 and Staphylococcus aureus 25923 in vitro. Results showed that antibacterial activity was significantly enhanced by the metal ions loaded, except for Fe2+. Especially for chitosan nanoparticles loaded Cu2+, the MIC and MBC against E. coli 25922, S.choleraesuis ATCC 50020 and S. aureus 25923 were 21-42 times lower than that of Cu2+, respectively. Moreover, it was found that antibacterial activity was directly proportional to zeta potential. (C) 2008 Published by Elsevier Ltd.

引用

页码：385 / 389

页数：5

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