Regulation of actin dynamics: The LIM kinase connection

被引:39
作者
Lawler, S [1 ]
机构
[1] Rayne Inst, Royal Free & Univ Coll Med Sch, Ctr Mol Med, London WC1E 6JJ, England
关键词
D O I
10.1016/S0960-9822(99)80493-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A signalling pathway has recently been delineated that connects Rho-family GTPases to the cytoskeleton via LIM kinase and the F-actin depolymerising protein cofilin. The existence of this pathway helps to explain some of the effects of LIM kinase and cofilin in the control of actin dynamics. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:R800 / R802
页数:3
相关论文
共 13 条
  • [1] Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
    Arber, S
    Barbayannis, FA
    Hanser, H
    Schneider, C
    Stanyon, CA
    Bernard, O
    Caroni, P
    [J]. NATURE, 1998, 393 (6687) : 805 - 809
  • [2] PAK to the future
    Bagrodia, S
    Cerione, RA
    [J]. TRENDS IN CELL BIOLOGY, 1999, 9 (09) : 350 - 355
  • [3] Putting a new twist on actin: ADF/cofilins modulate actin dynamics
    Bamburg, JR
    McGough, A
    Ono, S
    [J]. TRENDS IN CELL BIOLOGY, 1999, 9 (09) : 364 - 370
  • [4] Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
    Edwards, DC
    Sanders, LC
    Bokoch, GM
    Gill, GN
    [J]. NATURE CELL BIOLOGY, 1999, 1 (05) : 253 - 259
  • [5] Structural features of LIM kinase that control effects on the actin cytoskeleton
    Edwards, DC
    Gill, GN
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (16) : 11352 - 11361
  • [6] Rho GTPases and the actin cytoskeleton
    Hall, A
    [J]. SCIENCE, 1998, 279 (5350) : 509 - 514
  • [7] Protein-protein interaction of zinc finger LIM domains with protein kinase C
    Kuroda, S
    Tokunaga, C
    Kiyohara, Y
    Higuchi, O
    Konishi, H
    Mizuno, K
    Gill, GN
    Kikkawa, U
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (49) : 31029 - 31032
  • [8] Signaling from rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase
    Maekawa, M
    Ishizaki, T
    Boku, S
    Watanabe, N
    Fujita, A
    Iwamatsu, A
    Obinata, T
    Ohashi, K
    Mizuno, K
    Narumiya, S
    [J]. SCIENCE, 1999, 285 (5429) : 895 - 898
  • [9] Identification and characterization of a novel family of serine threonine kinases containing two N-terminal LIM motifs
    Okano, I
    Hiraoka, J
    Otera, H
    Nunoue, K
    Ohashi, K
    Iwashita, S
    Hirai, M
    Mizuno, K
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (52) : 31321 - 31330
  • [10] Signal transduction - Actin, cofilin and cognition
    Rosenblatt, J
    Mitchison, TJ
    [J]. NATURE, 1998, 393 (6687) : 739 - 740