Polymorphism of the renin-angiotensin-aldosterone system in patients with chronic allograft dysfunction

被引：11

作者：

Ayed, Kh. ^{[1
]}

Ayed-Jendoubi, S.

Ben Abdallah, T.

Bardia, R.

Gorgi, Y.

Sfar, I.

Dhrif, B.

Abderrahim, E.

Kheder, A.

机构：

[1] Immunol Lab EPS Ch Nicolle Hosp, Tunis, Tunisia

[2] Nephrol Dept EPS Ch Nicolle, Tunis, Tunisia

来源：

TRANSPLANT IMMUNOLOGY | 2006年 / 15卷 / 04期

关键词：

angiotensin converting enzyme; angiotensinogen AGT (M325T); ATR1 (A1166C); aldosterone synthase(CYP11B2); polymorphism; chronic allograft dysfunction;

D O I：

10.1016/j.trim.2005.09.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polymorphism of the gene encoding components of the renin-angiotensin-aldosterone synthase system (RAAS) represents an area of intense research of cardiovascular disease associations. Numerous studies have addressed the role of RAAS gene polymorphisms in the development and progression of renal disease. Also, it has been reported that patient with AGT (TT) and angiotensinogen AGT (TT) genotypes are associated with chronic allograft dysfunction (CAD). We investigated the effects of gene polymorphisms of the renin-angiotensin-aldosterone system in renal transplant patients (81 males and 50 females; mean age 29.6 +/- 10.2 years). Genotypes were determined using polymerase chain reaction sequence specific primers and PCR followed by RFLP analysis. Renal allograft recipients with chronic allograft dysfunction had significantly higher frequencies of the MM genotype than those without CAD (P<0.05). The other genetic polymorphisms of the RAAS were not associated with CAD. This study proves that determination of AGT M235T genotype before transplantation may help identify patients who are at risk for chronic renal transplant dysfunction. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：303 / 309

页数：7

共 59 条

[1] Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension [J].