Surgical resection versus percutaneous radiofrequency ablation in the treatment of hepatocellular carcinoma on cirrhotic liver

被引:267
作者
Vivarelli, M
Guglielmi, AF
Ruzzenente, A
Cucchetti, A
Bellusci, R
Cordiano, C
Cavallari, A
机构
[1] Univ Bologna, S Orsola Hosp, Dept Surg & Transplantat, Bologna, Italy
[2] Univ Verona, Dept Gen Surg 1, Maggiore Borgo Trento Hosp, Verona, Italy
关键词
D O I
10.1097/01.sla.0000129672.51886.44
中图分类号
R61 [外科手术学];
学科分类号
摘要
Objective: We sought to compare the experience of 2 different surgical units in the treatment of hepatocellular carcinoma (HCC) on cirrhosis with resection or percutaneous radiofrequency ablation (RFA), respectively. Summary Background Data: When allowed by the hepatic functional reserve, surgery is the therapy for HCC on cirrhosis; alternative treatments are proposed because of the high tumor recurrence rate after resection. RFA is being widely adopted to treat HCC. Methods: Over a 4-year period, 79 cirrhotics with HCC underwent resection in I surgical unit (group A) and another 79 had RFA at a different unit (group 13). Patient selection, operative mortality, hospital stay, and 1- and 3-year overall and disease-free survival were analyzed. Results: Group A (surgery): mean follow-up was 28.9 +/- 17.9 months; operative mortality was 3.8%, mean hospital stay 9 days; 1- and 3-year survival were, respectively, 83 and 65%. One- and 3-year disease-free survival were 79 and 50%. Group B (RFA): mean follow-up was 15.6 +/- 11.7 months. Mean hospital stay was I day (range 1-8). One- and 3-year survival were 78 and 33%; 1- and 3-year disease-free survival were 60 and 20%. Overall and disease-free survival were significantly higher in group A (P = 0.002 and 0.001). The advantage of surgery was more evident for Child-Pugh class A patients and for single tumors of more than 3 em in diameter. Results were similar in 2 groups for Child-Pugh class B patients. Conclusions: RFA has still to be confirmed as an alternative to surgery for potentially-resectable HCCs.
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页码:102 / 107
页数:6
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