Breastfeeding does not influence the development of inhibitors in haemophilia

被引：11

作者：

Knobe, KE ^{[1
]}

Tengborn, LI

Petrini, P

Ljung, RCR

机构：

[1] Univ Hosp, Dept Paediat, SE-20502 Malmo, Sweden

[2] Univ Hosp, Dept Coagulat Disorders, SE-20502 Malmo, Sweden

[3] Sahlgrens Univ Hosp, Dept Coagulat Disorders, Gothenburg, Sweden

[4] Karolinska Hosp, Dept Coagulat Disorders, S-10401 Stockholm, Sweden

来源：

HAEMOPHILIA | 2002年 / 8卷 / 05期

关键词：

breastfeeding; factor IX; factor VIII; haemophilia A; haemophilia B; inhibitor;

D O I：

10.1046/j.1365-2516.2002.00655.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Our aim was to test the hypothesis that breastfeeding may reduce development of inhibitors in male infants with haemophilia by inducing an oral immune tolerance to factor VIII. To achieve that goal, we performed a structured epidemiological survey comprising all males born with severe haemophilia A (in all 100 patients, 19 with inhibitors) or haemophilia B (in all 16 patients, six with inhibitors) in Sweden in 1980-99. Our results show no protective effect of breastfeeding.

引用

页码：657 / 659

页数：3

共 18 条

[1] FREQUENCY OF INHIBITOR DEVELOPMENT IN HEMOPHILIACS TREATED WITH LOW-PURITY FACTOR-VIII [J].