Sodium intake and hypertension

被引:353
作者
Karppanen, Heikki
Mervaala, Eero
机构
[1] Univ Helsinki, Inst Biomed, Pharmacol Biomed, FIN-00014 Helsinki, Finland
[2] Univ Kuopio, Dept Pharmacol & Toxicol, FIN-70211 Kuopio, Finland
基金
芬兰科学院;
关键词
D O I
10.1016/j.pcad.2006.07.001
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In current diets, the level of sodium is very high, whereas that of potassium, calcium, and magnesium is low compared with the level in diets composed of unprocessed, natural foods. We present the biologic rationale and scientific evidence that show that the current salt intake levels largely explain the high prevalence of hypertension. Comprehensive reduction of salt intake, both alone and particularly in combination with increases in intakes of potassium, calcium, and magnesium, is able to lower average blood pressure levels substantially. During the past 30 years, the one-third decrease in the average salt intake has been accompanied by a more than 10-mm Hg fall in the population average of both systolic and diastolic blood pressure, and a 75% to 80% decrease in both stroke and coronary heart disease mortality in Finland. There is no evidence of any harmful effects of salt reduction. Salt-reduction recommendations alone have a very small, if any, population impact. In the United States, for example, the per capita use of salt increased by approximately 55% from the mid-1980s to the late 1990s. We deal with factors that contribute toward increasing salt intakes and present examples of the methods that have contributed to the successful salt reduction in Finland. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:59 / 75
页数:17
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