Possible association of infertility with sperm-specific abnormality of CD46

被引：27

作者：

Kitamura, M

Matsumiya, K

Yamanaka, M

Takahara, S

Hara, T

Matsumoto, M

Namiki, M

Okuyama, A

Seya, T

机构：

[1] OSAKA UNIV,SCH MED,DEPT UROL,SUITA,OSAKA 565,JAPAN

[2] PRESTO,JRDC,KYOTO 619,JAPAN

来源：

JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1997年 / 33卷 / 01期

关键词：

infertility; CD46; sperm-egg interactions;

D O I：

10.1016/S0165-0378(97)01017-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three infertile patients fulfilling normal or subnormal criteria on routine semen analysis showed abnormal sperm CD46 (membrane cofactor protein of complement) by SDS-PAGE/immunoblotting analysis using a panel of monoclonal antibodies. The sperm CD46 isoform has been reported to be associated with sperm-egg interaction. These three patients expressed normal CD46 isoforms on their lymphocytes and granulocytes. Sperm-specific abnormalities in these proteins thus parallel male infertility, suggesting a new category of infertility, probably due to aberrations in the molecules related to sperm-egg interaction. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：83 / 88

页数：6

共 9 条

[1] THE ROLE OF COMPLEMENT COMPONENT C3B AND ITS RECEPTORS IN SPERM OOCYTE INTERACTION [J].