Protein turnover modifications induced by the protein feeding pattern still persist after the end of the diets

被引:33
作者
Arnal, MA
Mosoni, L
Boirie, Y
Gachon, P
Genest, M
Bayle, G
Grizard, J
Arnal, M
Antoine, JM
Beaufrère, B
Mirand, PP
机构
[1] INRA, UEMA, F-63122 Clermont Ferrand, France
[2] Ctr Rech Nutr Humaine, F-63122 Clermont Ferrand, France
[3] Univ Auvergne, Lab Nutr Humaine, F-63009 Clermont Ferrand, France
[4] Ctr Rech Nutr Humaine, F-63009 Clermont Ferrand, France
[5] Soc Danone, F-92350 Le Plessis Robinson, France
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2000年 / 278卷 / 05期
关键词
women; postabsorptive state; postprandial state; aging;
D O I
10.1152/ajpendo.2000.278.5.E902
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study was undertaken to determine whether the protein feeding pattern could induce chronic adaptation of protein turnover. After a 15-day adaptive period, elderly (68 yr) and young (26 yr) women received, for 14 days, a diet providing 200 KJ.kg fat-free mass (FFM)(-1).day(-1), where the daily protein intake (1.7 g protein.kg FFM-1.day(-1)) was either spread over 4 meals in the spread pattern or mainly (80%) consumed at noon in the pulse pattern. One day after the end of the dietary treatment, whole body leucine kinetics were measured by use of a continuous [C-13]leucine infusion, both in the postabsorptive state and in the same fed state. The pulse pattern was able to induce, in young as in elderly women, a lower postabsorptive leucine oxidation and endogenous leucine flux than the spread pattern and improved the responsiveness of nonoxidative leucine disposal during 4-h oral feeding. Thus the pulse pattern was able to induce chronic regulation of protein metabolism in young as in elderly women.
引用
收藏
页码:E902 / E909
页数:8
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