Model of the c-subunit oligomer in the membrane domain of F-ATPases

被引：39

作者：

Groth, G ^{[1
]}

Walker, JE ^{[1
]}

机构：

[1] MRC,MOL BIOL LAB,CAMBRIDGE CB2 2QH,ENGLAND

来源：

FEBS LETTERS | 1997年 / 410卷 / 2-3期

关键词：

F-ATPase; oligomeric transmembrane complex; proteolipid; molecular model;

D O I：

10.1016/S0014-5793(97)00529-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A model is described of a dodecameric complex consisting of the integral membrane component subunit c of the H+-transporting F-0 domain of Escherichia coli F-ATPase. A high-resolution partial structure of monomeric subunit c resulting from H-1-NMR studies [1] was used for constructing the model. The validity of the proposed arrangement of protomers in the dodecameric complex was tested by amino acid substitution analysis and chemical, biochemical and genetic data on submit c. (C) 1997 Federation of European Biochemical Societies.

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页码：117 / 123

页数：7

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