A sultone approach to the C(1)-C(18) moiety of pamamycin-607

被引：31

作者：

Bernsmann, H

Fröhlich, R

Metz, P

机构：

[1] Tech Univ Dresden, Inst Organ Chem, D-01062 Dresden, Germany

[2] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 22期

关键词：

antibiotics; Diels-Alder reactions; sultones; hydroboration;

D O I：

10.1016/S0040-4039(00)00659-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly advanced enantiomerically pure C(1)-C(18) precursor of the larger fragment of the macro-diolide pamamycin-607 has been synthesized. The stereotriad C(7)-C(9) between the two heterocyclic rings of the target was generated using a diastereoselective hydroboration controlled by minimization of allylic 1,3-strain. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4347 / 4351

页数：5

共 30 条

[1]

Arista L, 1997, SYNLETT, P627

[2] CONVENIENT GENERAL-METHOD FOR THE PREPARATION OF PRIMARY ALKYLLITHIUMS BY LITHIUM IODINE EXCHANGE [J].