Preclinical and clinical safety studies on DNA vaccines

被引：96

作者：

Schalk, Johanna A. C.

Mooi, Frits R.

Berbers, Guy A. M.

van Aerts, Leon A. G. J. M.

Ovelgonne, Hans

Kimman, Tieerd G.

机构：

[1] Natl Inst Publ Hlth & Environm, Ctr Biol Med & Med Technol, NL-3720 BA Bilthoven, Netherlands

[2] Natl Inst Publ Hlth & Environm, Lab Vaccine Preventable Dis, NL-3720 BA Bilthoven, Netherlands

来源：

HUMAN VACCINES | 2006年 / 2卷 / 02期

关键词：

DNA vaccines; safety; integration; vertical transmission; auto-immunity; immunological tolerance; immunotoxicity; toxicity; environmental safety;

D O I：

10.4161/hv.2.2.2620

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

DNA vaccines are based on the transfer of genetic material, encoding an antigen, to the cells of the vaccine recipient. Despite high expectations of DNA vaccines as a result of promising preclinical data their clinical utility remains unproven. However, much data is gathered in preclinical and clinical studies about the safety of DNA vaccines. Here we review current knowledge about the safety of DNA vaccines. Safety concerns of DNA vaccines relate to genetic, immunologic, toxic, and environmental effects. In this review we provide an overview of findings related to the safety of DNA vaccines, obtained so far. We conclude that the potential risks of DNA vaccines are minimal. However, their safety issues may differ case-by-case, and they should be treated accordingly.

引用

页码：45 / 53

页数：9

共 90 条

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