New targets of AMP-activated protein kinase

被引：41

作者：

Hue, L

Beauloye, C

Bertrand, L

Horman, S

Krause, U

Marsin, AS

Meisse, D

Vertommen, D

Rider, MH

机构：

[1] Inst Cellular Pathol, Hormone & Metab Res Unit, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Sch Med, UCL 7529, B-1200 Brussels, Belgium

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷

关键词：

apoptosis; glycolysis; Pasteur Effect; protein synthesis;

D O I：

10.1042/bst0310213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The discovery of the AMP-activated protein kinase (AMPK) more than a decade ago has shed much light on the cellular response to stresses characterized by a fall in the concentration of ATP and an increase in the AMP/ATP ratio. All conditions known to increase this ratio activate AMPK, whose major role is to act as an emergency signal to conserve ATP. It does so by inhibiting anabolic processes and by activating pathways producing ATP. In recent years, our laboratory has discovered new targets of AMPK. The purpose of this short review is to; summarize our contribution to this field.

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收藏

页码：213 / 215

页数：3

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[1] Insulin antagonizes AMP-activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides [J].

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Krause, U ;

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[2] The stimulation of heart glycolysis by increased workload does not require AMP-activated protein kinase but a wortmannin-sensitive mechanism [J].

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Vanoverschelde, JL ;

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[3] Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats [J].

Bergeron, R ;

Previs, SF ;

Cline, GW ;

Perret, P ;

Russell, RR ;

Young, LH ;

Shulman, GI .

DIABETES, 2001, 50 (05) :1076-1082

[4] Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B [J].

Bertrand, L ;

Alessi, DR ;

Deprez, J ;

Deak, M ;

Viaene, E ;

Rider, MH ;

Hue, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (43) :30927-30933

[5] Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy:: evidence for the central role of energy compromise in disease pathogenesis [J].

Blair, E ;

Redwood, C ;

Ashrafian, H ;

Oliveira, M ;

Broxholme, J ;

Kerr, B ;

Salmon, A ;

Östman-Smith, I ;

Watkins, H .

HUMAN MOLECULAR GENETICS, 2001, 10 (11) :1215-1220

[6] The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes [J].

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Geelen, MJH ;

Velasco, G ;

Guzmán, M .

FEBS LETTERS, 2001, 489 (2-3) :149-153

[7] AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. [J].

Bolster, DR ;

Crozier, SJ ;

Kimball, SR ;

Jefferson, LS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (27) :23977-23980

[8] AMP-activated protein kinase phosphorylation of endothelial NO synthase [J].

Chen, ZP ;

Mitchelhill, KI ;

Michell, BJ ;

Stapleton, D ;

Rodriguez-Crespo, I ;

Witters, LA ;

Power, DA ;

de Montellano, PRO ;

Kemp, BE .

FEBS LETTERS, 1999, 443 (03) :285-289

[9] An inducible gene product for 6-phosphofructo-2-kinase with an AU-rich instability element: Role in tumor cell glycolysis and the Warburg effect [J].

Chesney, J ;

Mitchell, R ;

Benigni, F ;

Bacher, M ;

Spiegel, L ;

Al-Abed, Y ;

Han, JH ;

Metz, C ;

Bucala, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3047-3052

[10] 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOSIDE - A SPECIFIC METHOD FOR ACTIVATING AMP-ACTIVATED PROTEIN-KINASE IN INTACT-CELLS [J].

CORTON, JM ;

GILLESPIE, JG ;

HAWLEY, SA ;

HARDIE, DG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1995, 229 (02) :558-565

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