TGF-beta in CAF-mediated tumor growth and metastasis

被引：267

作者：

Calon, A. ^{[1
]}

Tauriello, D. V. F. ^{[1
]}

Batlle, E. ^{[1
,2
]}

机构：

[1] Inst Biomed Res, Dept Oncol, Barcelona 08028, Spain

[2] Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain

来源：

SEMINARS IN CANCER BIOLOGY | 2014年 / 25卷

基金：

欧洲研究理事会;

关键词：

TGF-beta; Tumor microenvironment; Cancer-associated fibroblast; Metastasis; Stroma; CANCER-ASSOCIATED FIBROBLASTS; CARCINOMA-ASSOCIATED FIBROBLASTS; MATRIX-METALLOPROTEINASE INHIBITORS; STEM-CELLS DIFFERENTIATE; BREAST-CANCER; COLON-CANCER; STROMAL FIBROBLASTS; GENE-EXPRESSION; TRANSFORMING GROWTH-FACTOR-BETA-1; MESENCHYMAL TRANSITION;

D O I：

10.1016/j.semcancer.2013.12.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TGF-beta signaling is one of the major pathways controlling cell and tissue behavior not only in homeostasis but also in disease. During tumorigenesis TGF-beta orchestrated processes are key due to its dual role as tumor suppressor and tumor promoter. Important functions of this pathway have been described in a context-dependent manner both in epithelial cancer cells and in the tumor microenvironment during tumor progression. Carcinoma-associated fibroblasts (CAFs) are one of the most abundant stromal cell types in virtually all solid tumors. CAFs favor malignant progression by providing cancer cells with proliferative, migratory, survival and invasive capacities. A complex network of signaling pathways underlying their tumor-promoting properties is beginning to take shape. In this review, we examine current evidence on the emerging mechanisms involving TGF-beta in CAF-mediated cancer progression, and discuss their potential as therapeutic targets. (C) 2014 Elsevier Ltd. All rights reserved.

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页码：15 / 22

页数：8

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