Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

被引：152

作者：

Baik, Sung Hoon ^{[1
]}

Cha, Moon-Yong ^{[1
]}

Hyun, Young-Min ^{[2
]}

Cho, Hansang ^{[4
]}

Hamza, Bashar ^{[4
]}

Kim, Dong Kyu ^{[1
]}

Han, Sun-Ho ^{[1
]}

Choi, Heesun ^{[1
]}

Kim, Kyung Ho ^{[1
]}

Moon, Minho ^{[1
]}

Lee, Jeewoo ^{[3
]}

Kim, Minsoo ^{[1
,2
]}

Irimia, Daniel ^{[4
]}

Mook-Jung, Inhee ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Med, Dept Biochem & Biomed Sci, Seoul 110799, South Korea

[2] Univ Rochester, David H Smith Ctr Vaccine Biol & Immunol, Dept Microbiol & Immunol, Rochester, NY USA

[3] Seoul Natl Univ, Coll Pharm, Dept Pharmacol, Seoul, South Korea

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, BioMEMS Resource Ctr, Boston, MA USA

来源：

NEUROBIOLOGY OF AGING | 2014年 / 35卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Alzheimer's disease; Neutrophils; Amyloid plaques; Immune cells; INNATE IMMUNE-RESPONSE; TRANSGENIC MICE; BETA; BRAIN; NEURODEGENERATION; MICROGLIA; SYSTEM;

D O I：

10.1016/j.neurobiolaging.2014.01.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

030301 [社会学]; 100201 [内科学];

摘要：

Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：1286 / 1292

页数：7

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