Fabrication of MnxFe1-xO Colloidal Solid Solution as a Dual Magnetic-Resonance-Contrast Agent

被引：34

作者：

Choi, Donghyeuk ^{[1
]}

Han, Anna ^{[1
]}

Park, Joong Pill ^{[1
]}

Kim, Jai Keun ^{[2
]}

Lee, Jei Hee ^{[2
]}

Kim, Tae Hee ^{[2
]}

Kim, Sang-Wook ^{[1
]}

机构：

[1] Ajou Univ, Dept Mol Sci & Technol, Suwon 443749, South Korea

[2] Ajou Univ, Sch Med, Dept Radiol, Suwon 443749, South Korea

来源：

SMALL | 2009年 / 5卷 / 05期

关键词：

contrast agents; iron; magnetic resonance imaging; manganese; nanocrystalline materials; MRI; NANOCRYSTALS;

D O I：

10.1002/smll.200801258

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A study was conducted to demonstrate the fabrication of colloidal Mn xFe1-xO solid-solution nanocrystals and their application as a simultaneous and dual MRI contrast agent for T1- and T 2--weighted imaging. MnxFe1-xO solid-solution nanocrystals were synthesized by the thermal decomposition of iron acetylacetonate(III) and manganese acetylacetonate(II) precursors. Elemental analysis of the solid solution was performed by inductively coupled plasma-atomic emission spectroscopy (ICP-AES) and the energy-dispersive X-ray spectroscopy. Transmission electron microscopy (TEM) investigation revealed 20 nm nanocrystals with a crystalline structure. MRI measurements were also performed on a clinical 1.5-T magnetic resonance scanner at room temperature for three different water-dispersible MnxFe1-xO nanocrystals.

引用

页码：571 / 573

页数：3

共 23 条

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