Polysomes, P bodies and stress granules: states and fates of eukaryotic mRNAs

被引:301
作者
Balagopal, Vidya
Parker, Roy [1 ]
机构
[1] Univ Arizona, Dept Mol & Cellular Biol, Tucson, AZ 85721 USA
关键词
PROCESSING BODIES; BODY FORMATION; TRANSLATION; DECAY; ASSOCIATION; INITIATION; COMPONENT; PROTEINS; MICRORNA; REQUIRES;
D O I
10.1016/j.ceb.2009.03.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The control of translation and mRNA degradation plays a key role in the regulation of eukaryotic gene expression. In the cytosol, mRNAs engaged in translation are distributed throughout the cytosol, while translationally inactive mRNAs can accumulate in P bodies, in complex with mRNA degradation and translation repression machinery, or in stress granules, which appear to be mRNAs stalled in translation initiation. Here we discuss how these different granules suggest a dynamic model for the metabolism of cytoplasmic mRNAs wherein they cycle between different mRNP states with different functional properties and subcellular locations.
引用
收藏
页码:403 / 408
页数:6
相关论文
共 57 条
[1]   The Dynamics of Mammalian P Body Transport, Assembly, and Disassembly In Vivo [J].
Aizer, Adva ;
Brody, Yehuda ;
Ler, Lian Wee ;
Sonenberg, Nahum ;
Singer, Robert H. ;
Shav-Tal, Yaron .
MOLECULAR BIOLOGY OF THE CELL, 2008, 19 (10) :4154-4166
[2]   A place for RNAi [J].
Anderson, P .
DEVELOPMENTAL CELL, 2005, 9 (03) :311-312
[3]   RNA granules [J].
Anderson, P ;
Kedersha, N .
JOURNAL OF CELL BIOLOGY, 2006, 172 (06) :803-808
[4]   Stress granules: The Tao of RNA triage [J].
Anderson, Paul ;
Kedersha, Nancy .
TRENDS IN BIOCHEMICAL SCIENCES, 2008, 33 (03) :141-150
[5]   A role for eIF4E and eIF4E-transporter in targeting mRNPs to mammalian processing bodies [J].
Andrei, MA ;
Ingelfinger, D ;
Heintzmann, R ;
Achsel, T ;
Rivera-Pomar, R ;
Lührmann, R .
RNA, 2005, 11 (05) :717-727
[6]   Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways [J].
Arimoto, Kyoko ;
Fukuda, Hiroyuki ;
Imajoh-Ohmi, Shinobu ;
Saito, Haruo ;
Takekawa, Mutsuhiro .
NATURE CELL BIOLOGY, 2008, 10 (11) :1324-U167
[7]  
BEELMAN CA, 1994, J BIOL CHEM, V269, P9687
[8]   MRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes [J].
Behm-Ansmant, Isabelle ;
Rehwinkel, Jan ;
Doerks, Tobias ;
Stark, Alexander ;
Bork, Peer ;
Izaurralde, Elisa .
GENES & DEVELOPMENT, 2006, 20 (14) :1885-1898
[9]   Stress-induced reversal of microRNA repression and mRNA P-body localization in human cells [J].
Bhattacharyya, S. N. ;
Habermacher, R. ;
Martine, U. ;
Closs, E. I. ;
Filipowicz, W. .
COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2006, 71 :513-521
[10]   Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodies [J].
Brengues, M ;
Teixeira, D ;
Parker, R .
SCIENCE, 2005, 310 (5747) :486-489