Association of peripheral mononuclear cells containing Chlamydia pneumoniae DNA with acute coronary syndrome and stable coronary artery disease in Japanese subjects

被引：8

作者：

Aso, N ^{[1
]}

Tamura, A ^{[1
]}

Kadota, J ^{[1
]}

Nasu, M ^{[1
]}

机构：

[1] Oita Univ, Fac Med, Dept Internal Med 2, Oita 87011, Japan

来源：

CLINICAL INFECTIOUS DISEASES | 2004年 / 39卷 / 03期

关键词：

D O I：

10.1086/422316

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To clarify the association of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells (PBMCs) with acute coronary syndrome (ACS) and stable coronary artery disease (CAD) in Japanese adults, touchdown-nested polymerase chain reaction was used to detect the presence of C. pneumoniae DNA. The prevalence of C. pneumoniae DNA in PBMCs was similar in a comparison of 88 patients (52.3%) with ACS, 164 patients (50.0%) with stable CAD, and 88 control subjects (50.0%). Temporal changes in the prevalence of C. pneumoniae DNA in PBMCs were also assessed every 3 months during a 1-year period (n = 59). The prevalence was significantly higher in the first 3-month period (January through March) than in any of the other 3-month periods. In conclusion, the prevalence of C. pneumoniae DNA in PBMCs in patients with ACS or stable CAD was comparable to that in control populations. Furthermore, the presence of circulating C. pneumoniae was strongly associated with seasonal variability.

引用

页码：366 / 372

页数：7

共 48 条

[1] Chlamydia pneumoniae DNA in non-coronary atherosclerotic plaques and circulating leukocytes [J].

Berger, M ;

Schröder, B ;

Daeschlein, G ;

Schneider, W ;

Busjahn, A ;

Buchwalow, I ;

Luft, FC ;

Haller, H .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 2000, 136 (03) :194-200

[2] Chlamydia pneumoniae DNA detection in peripheral blood mononuclear cells is predictive of vascular infection [J].

Blasi, F ;

Boman, J ;

Esposito, G ;

Melissano, G ;

Chiesa, R ;

Cosentini, R ;

Tarsia, P ;

Tshomba, Y ;

Betti, M ;

Alessi, M ;

Morelli, N ;

Allegra, L .

JOURNAL OF INFECTIOUS DISEASES, 1999, 180 (06) :2074-2076

[3] High prevalence of Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in patients with cardiovascular disease and in middle-aged blood donors [J].

Boman, J ;

Söderberg, S ;

Forsberg, J ;

Birgander, LS ;

Allard, A ;

Persson, K ;

Jidell, E ;

Kumlin, U ;

Juto, P ;

Waldenström, A ;

Wadell, G .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (01) :274-277

[4] UNSTABLE ANGINA - A CLASSIFICATION [J].

BRAUNWALD, E .

CIRCULATION, 1989, 80 (02) :410-414

[5] Peripheral-blood-based PCR assay to identify patients with active pulmonary tuberculosis [J].

Condos, R ;

McClune, A ;

Rom, WN ;

Schluger, NW .

LANCET, 1996, 347 (9008) :1082-1085

[6] Chlamydia pneumoniae infection of vascular smooth muscle and endothelial cells activates NF-κB and induces tissue factor and PAI-1 expression -: A potential link to accelerated arteriosclerosis [J].

Dechend, R ;

Maass, M ;

Gieffers, J ;

Dietz, R ;

Scheidereit, C ;

Leutz, A ;

Gulba, DC .

CIRCULATION, 1999, 100 (13) :1369-1373

[7] Standardizing Chlamydia pneumoniae assays:: Recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada) [J].

Dowell, SF ;

Peeling, RW ;

Boman, J ;

Carlone, GM ;

Fields, BS ;

Guarner, J ;

Hammerschlag, MR ;

Jackson, LA ;

Kuo, CC ;

Maass, M ;

Messmer, TO ;

Talkington, DF ;

Tondella, ML ;

Zaki, SR ;

Bandea, C ;

Black, C ;

O'Conner, S ;

Papp, J ;

Perilla, MJ ;

Schuchat, A ;

Stevens, V ;

Van Beneden, CA ;

Zell, ER ;

Cohen, C ;

Campbell, LA ;

Wwang, SP ;

Grayston, JT ;

Deal, CD ;

Gaydos, C ;

Schindler, L ;

Taylor, CE ;

Mahony, J ;

Fong, IW ;

Leinonen, M ;

Saikku, P ;

Maas, M ;

Ossewaarde, JM ;

Persson, K ;

Boman, J ;

Apfalter, P .

CLINICAL INFECTIOUS DISEASES, 2001, 33 (04) :492-502

[8] Chlamydia pneumoniae DNA in peripheral venous blood samples from patients with carotid artery stenosis [J].

Freidank, HM ;

Lux, A ;

Dern, P ;

Meyer-König, U ;

Els, T .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2002, 21 (01) :60-62

[9]

Fryer RH, 1997, J INVEST MED, V45, P168

[10] The prevalence of chronic Chlamydia pneumoniae infection as detected by polymerase chain reaction in pharyngeal samples from patients with ischaemic heart disease [J].

Gabriel, AS ;

Gnarpe, H ;

Gnarpe, J ;

Hallander, H ;

Nyquist, O ;

Martinsson, A .

EUROPEAN HEART JOURNAL, 1998, 19 (09) :1321-1327

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