Oxidative challenge in Alzheimer's disease: state of knowledge and future needs

被引：71

作者：

Cervellati, Carlo ^{[1
]}

Wood, Paul L. ^{[2
]}

Romani, Arianna ^{[1
]}

Valacchi, Giuseppe ^{[3
,4
]}

Squerzanti, Monica ^{[1
]}

Sanz, Juana Maria ^{[5
]}

Ortolani, Beatrice ^{[5
]}

Zuliani, Giovanni ^{[5
]}

机构：

[1] Univ Ferrara, Sect Med Biochem Mol Biol & Genet, Dept Biomed & Specialist Surg Sci, Via Luigi Borsari 46, I-44121 Ferrara, Italy

[2] Lincoln Mem Univ, Metabol Unit, Math & Sci Bldg, Harrogate, TN USA

[3] Univ Ferrara, Dept Life Sci & Biotechnol, I-44121 Ferrara, Italy

[4] Kyung Hee Univ, Dept Food & Nutr, Seoul, South Korea

[5] Univ Ferrara, Sect Internal & CardioResp Med, Dept Med Sci, I-44121 Ferrara, Italy

来源：

JOURNAL OF INVESTIGATIVE MEDICINE | 2016年 / 64卷 / 01期

关键词：

Alzheimer Disease; Oxidants; Biological Markers; Antioxidants; Dementia; MILD COGNITIVE IMPAIRMENT; DENSITY-LIPOPROTEIN OXIDATION; LIPID-PEROXIDATION; MITOCHONDRIAL DYSFUNCTION; CEREBROSPINAL-FLUID; PROTEIN OXIDATION; REACTIVE OXYGEN; OLDER PATIENTS; DNA-DAMAGE; HIPPOCAMPAL ATROPHY;

D O I：

10.1136/jim-2015-000017

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

A large body of experimental and postmortem findings indicate that Alzheimer's disease (AD) is associated with increased oxidative stress (OxS) levels in the brain. Despite the current limitations of OxS assessment in living subjects, recent data suggest that oxidative challenge might increase early both in the central nervous system and peripheral fluids. The aim of this review was to provide an overview of the existing literature linking systemic OxS to brain OxS in AD. We firmly believe that continued research aimed at overcoming the methodological and design issues affecting the body of studies in this field is mandatory for successful development of an effective antioxidant-based treatment of AD.

引用

页码：21 / 32

页数：12

共 163 条

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