Proteomics: addressing the challenges of osteoarthritis

被引：15

作者：

De Ceuninck, Frederic ^{[1
]}

Berenbaum, Francis ^{[2
]}

机构：

[1] Servier Res Inst, Dept Rheumatol, F-92150 Suresnes, France

[2] Univ Paris 06, UR 4, AP HP, St Antoine Hosp, F-75012 Paris, France

来源：

DRUG DISCOVERY TODAY | 2009年 / 14卷 / 13-14期

关键词：

HUMAN ARTICULAR-CARTILAGE; MATRIX METALLOPROTEINASES; DIFFERENTIAL PROTEOME; SYNOVIAL-FLUID; CHONDROCYTES; IDENTIFICATION; PROTEINS; AUTOIMMUNITY; EXPRESSION; ARTHRITIS;

D O I：

10.1016/j.drudis.2009.05.006

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Osteoarthritis (OA) is the most frequent rheumatic disease and is the leading cause of disability in developed countries. Its poorly understood pathophysiology limits the discovery of targets for pharmacological intervention and there are few effective medical. treatments beyond pain control and surgery. Proteomic technologies may help identifying new targets of OA as well as diagnostic or therapeutic biomarkers, which has stimulated interest in this field. In this review, we discuss the most recent findings arising from the use of proteomics for the identification of OA biomarkers in synovial fluid and serum, and for the discovery of possible therapeutic targets in cartilage or by using chondrocyte culture systems.

引用

页码：661 / 667

页数：7

共 44 条

[1]

Blanco FJ, 2007, BIOMED HEALTH RES, V70, P192

[2]

Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M [J].

Catterall, J. B. ;

Rowan, A. D. ;

Sarsfield, S. ;

Saklatvala, J. ;

Wait, R. ;

Cawston, T. E. .

RHEUMATOLOGY, 2006, 45 (09) :1101-1109

[3]

High binding capacity of cyclophilin B to chondrocyte heparan sulfate proteoglycans and its release from the cell surface by matrix metalloproteinases - Possible role as a proinflammatory mediator in arthritis [J].

De Ceuninck, F ;

Allain, F ;

Caliez, A ;

Spik, G ;

Vanhoutte, PM .

ARTHRITIS AND RHEUMATISM, 2003, 48 (08) :2197-2206

[4]

YKL-40 (cartilage gp-39) induces proliferative events in cultured chondrocytes and synoviocytes and increases glycosaminoglycan synthesis in chondrocytes [J].

De Ceuninck, F ;

Gaufillier, S ;

Bonnaud, A ;

Sabatini, M ;

Lesur, C ;

Pastoureau, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 285 (04) :926-931

[5]

De Ceuninck Frederic, 2005, J Biomol Tech, V16, P256

[6]

DECEUNINCK F, 2004, BIOCHEM BIOPH RES CO, V285, P926

[7]

Freyria AM, 2004, METH MOLEC MED, V100, P165

[8]

Protein profile of osteoarthritic human articular cartilage using tandem mass spectrometry [J].

Garcia, Benjamin A. ;

Platt, Mark D. ;

Born, Timothy L. ;

Shabanowitz, Jeffrey ;

Marcus, Norman A. ;

Hunt, Donald F. .

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2006, 20 (20) :2999-3006

[9]

High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis [J].

Gobezie, Reuben ;

Kho, Alvin ;

Krastins, Bryan ;

Sarracino, David A. ;

Thornhill, Thomas S. ;

Chase, Michael ;

Millett, Peter J. ;

Lee, David M. .

ARTHRITIS RESEARCH & THERAPY, 2007, 9 (02)

[10]

Proteomic analysis of human articular cartilage: Identification of differentially expressed proteins in knee osteoarthritis [J].

Guo, Dunming ;

Tan, Wenfeng ;

Wang, Fang ;

Lv, Zheng ;

Hu, Jun ;

Lv, Tianrun ;

Chen, Qun ;

Gu, Xiaoyuan ;

Wan, Bing ;

Zhang, Zhongnan .

JOINT BONE SPINE, 2008, 75 (04) :439-444

← 1 2 3 4 5 →