The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

被引：55

作者：

Dellovade, TL

Chan, J

Vennstrom, B

Forrest, D

Pfaff, DW

机构：

[1] Rockefeller Univ, Neurobiol & Behav Lab, New York, NY 10021 USA

[2] Karolinska Inst, Dept Cell & Mol Biol, Dev Biol Lab, Stockholm, Sweden

[3] CUNY Mt Sinai Sch Med, Dept Human Genet, New York, NY 10029 USA

来源：

NATURE NEUROSCIENCE | 2000年 / 3卷 / 05期

关键词：

D O I：

10.1038/74846

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The two genes coding for thyroid hormone receptors (TR) alpha 1 and beta have opposite effects on female sex behaviors. Deletion of TR alpha 1 reduced them, whereas deletion of TRP actually increased them. These results could not be attributed to altered levers of hormones in the blood, general alterations in estrogen responsiveness or altered general activity. Instead, they indicate a previously unknown molecular mechanism upon which the two TR genes exert opposite influences.

引用

收藏

页码：472 / 475

页数：4

相关论文

共 31 条

[1]

[Anonymous], [No title captured]

[2] Absence of thyroid hormone receptor β-retinoid X receptor interactions in auditory function and in the pituitary-thyroid axis [J].

Barros, AC ;

Erway, LC ;

Krezel, W ;

Curran, T ;

Kastner, P ;

Chambon, P ;

Forrest, D .

NEUROREPORT, 1998, 9 (13) :2933-2937

[3]

Carter C S, 1997, Ann N Y Acad Sci, V807, pxiii, DOI 10.1111/j.1749-6632.1997.tb51909.x

[4] Two separate NCoR (nuclear receptor corepressor) interaction domains mediate corepressor action on thyroid hormone response elements [J].

Cohen, RN ;

Wondisford, FE ;

Hollenberg, AN .

MOLECULAR ENDOCRINOLOGY, 1998, 12 (10) :1567-1581

[5] THYROXINE IS PERMISSIVE TO SEASONAL TRANSITIONS IN REPRODUCTIVE NEUROENDOCRINE ACTIVITY IN THE EWE [J].

DAHL, GE ;

EVANS, NP ;

THRUN, LA ;

KARSCH, FJ .

BIOLOGY OF REPRODUCTION, 1995, 52 (03) :690-696

[6] Thyroid hormone coadministration inhibits the estrogen-stimulated elevation of preproenkephalin mRNA in female rat hypothalamic neurons [J].

Dellovade, TL ;

Kia, HK ;

Zhu, YS ;

Pfaff, DW .

NEUROENDOCRINOLOGY, 1999, 70 (03) :168-174

[7] Thyroid hormones and estrogen affect oxytocin gene expression in hypothalamic neurons [J].

Dellovade, TL ;

Zhu, YS ;

Pfaff, DW .

JOURNAL OF NEUROENDOCRINOLOGY, 1999, 11 (01) :1-10

[8] Thyroid hormone and estrogen interact to regulate behavior [J].

Dellovade, TL ;

Zhu, YS ;

Krey, L ;

Pfaff, DW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (22) :12581-12586

[9] EFFECT OF VARYING THE DURATION OF PRETEST CAGE HABITUATION ON OXYTOCIN INDUCTION OF SHORT-LATENCY MATERNAL-BEHAVIOR [J].

FAHRBACH, SE ;

MORRELL, JI ;

PFAFF, DW .

PHYSIOLOGY & BEHAVIOR, 1986, 37 (01) :135-139

[10] Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: Evidence for tissue-specific modulation of receptor function [J].

Forrest, D ;

Hanebuth, E ;

Smeyne, RJ ;

Everds, N ;

Stewart, CL ;

Wehner, JM ;

Curran, T .

EMBO JOURNAL, 1996, 15 (12) :3006-3015

← 1 2 3 4 →