Bioactive sphingolipids: metabolism and function

被引：550

作者：

Bartke, Nana ^{[1
]}

Hannun, Yusuf A. ^{[1
]}

机构：

[1] Med Univ S Carolina, Dept Biochem & Mol Biol, Charleston, SC 29425 USA

来源：

JOURNAL OF LIPID RESEARCH | 2009年 / 50卷

基金：

美国国家卫生研究院;

关键词：

ceramide; bioactive lipids; compartmentalization; PROTEIN-KINASE-C; CERAMIDE; 1-PHOSPHATE; SPHINGOSINE; NEUTRAL SPHINGOMYELINASE; EPITHELIAL-CELLS; APOPTOSIS; SPHINGOSINE-1-PHOSPHATE; ACTIVATION; ROLES; MEMBRANE;

D O I：

10.1194/jlr.R800080-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Sphingolipids (SLs) are essential constituents of eukaryotic cells. Besides playing structural roles in cellular membranes, some metabolites, including ceramide, sphingosine, and sphingosine-1-phosphate, have drawn attention as bioactive signaling molecules involved in the regulation of cell growth, differentiation, senescence, and apoptosis. Understanding the many cell regulatory functions of SL metabolites requires an advanced knowledge of how and where in the cell they are generated, converted, or degraded.jlr This review will provide a short overview of the metabolism, localization, and compartmentalization of SLs. Also, a discussion on bioactive members of the SL family and inducers of SL enzymes that lead to ceramide generation will be presented. -Bartke, N., and Y. A. Hannun. Bioactive sphingolipids: metabolism and function. J. Lipid Res. 2009. S91-S96.

引用

页码：S91 / S96

页数：6

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