Harnessing dynamic combinatorial chemistry in the search for new ligands for protein targets

被引：8

作者：

Monjas, Leticia ^{[1
]}

Hirsch, Anna K. H. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

FUTURE MEDICINAL CHEMISTRY | 2015年 / 7卷 / 16期

关键词：

drug discovery; dynamic combinatorial chemistry; inhibitors; molecular recognition; NEURAMINIDASE INHIBITORS; NUCLEOPHILIC CATALYSIS; LIBRARIES; IDENTIFICATION; GENERATION; DISCOVERY; SELECTION; RESIN; TOOL;

D O I：

10.4155/fmc.15.146

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

[No abstract available]

引用

页码：2095 / 2098

页数：4

共 19 条

[1]

Affinity chromatography in dynamic combinatorial libraries: one-pot amplification and isolation of a strongly binding receptor [J].

Besenius, Pol ;

Cormack, Peter A. G. ;

Ludlow, R. Frederick ;

Otto, Sijbren ;

Sherrington, David C. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, 8 (10) :2414-2418

[2]

Bhat VT, 2010, NAT CHEM, V2, P490, DOI [10.1038/nchem.658, 10.1038/NCHEM.658]

[3]

Direct STD NMR Identification of β-Galactosidase Inhibitors from a Virtual Dynamic Hemithioacetal System [J].

Caraballo, Remi ;

Dong, Hai ;

Ribeiro, Joao P. ;

Jimenez-Barbero, Jesus ;

Ramstrom, Olof .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (03) :589-593

[4]

NUCLEOPHILIC CATALYSIS OF SEMICARBAZONE FORMATION BY ANILINES [J].

CORDES, EH ;

JENCKS, WP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1962, 84 (05) :826-&

[5]

A novel protocol to accelerate dynamic combinatorial chemistry via isolation of ligand-target adducts from dynamic combinatorial libraries: A case study identifying competitive inhibitors of lysozyme [J].

Fang, Zheng ;

He, Wei ;

Li, Xin ;

Li, Zhengjiang ;

Chen, Beining ;

Ouyang, Pingkai ;

Guo, Kai .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (18) :5174-5177

[6]

Dynamic Combinatorial Selection of Molecules Capable of Inhibiting the (CUG) Repeat RNA-MBNL1 Interaction In Vitro: Discovery of Lead Compounds Targeting Myotonic Dystrophy (DM1) [J].

Gareiss, Peter C. ;

Sobczak, Krzysztof ;

McNaughton, Brian R. ;

Palde, Prakash B. ;

Thornton, Charles A. ;

Miller, Benjamin L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (48) :16254-16261

[7]

Dynamic covalent capture of hydrazides by a phosphonate-target immobilized on resin [J].

Gasparini, Giulio ;

Rastrelli, Federico ;

Prins, Leonard J. .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 11 (38) :6580-6587

[8]

Dynamic combinatorial/covalent chemistry: a tool to read, generate and modulate the bioactivity of compounds and compound mixtures [J].

Herrmann, Andreas .

CHEMICAL SOCIETY REVIEWS, 2014, 43 (06) :1899-1933

[9]

Ketones as building blocks for dynamic combinatorial libraries:: Highly active neuraminidase inhibitors generated via selection pressure of the biological target [J].

Hochgürtel, M ;

Biesinger, R ;

Kroth, H ;

Piecha, D ;

Hofmann, MW ;

Krause, S ;

Schaaf, O ;

Nicolau, C ;

Eliseev, AV .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (03) :356-358

[10]

Target-induced formation of neuraminidase inhibitors from in vitro virtual combinatorial libraries [J].

Hochgürtel, M ;

Kroth, H ;

Piecha, D ;

Hofmann, MW ;

Nicolau, C ;

Krause, S ;

Schaaf, O ;

Sonnenmoser, G ;

Eliseev, AV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3382-3387

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