Therapeutic benefits from targeting of ADAM family members

被引：104

作者：

Moss, ML

Bartsch, JW

机构：

[1] BioZyme Inc, Apex, NC 27523 USA

[2] Univ Bielefeld, D-33501 Bielefeld, Germany

来源：

BIOCHEMISTRY | 2004年 / 43卷 / 23期

关键词：

D O I：

10.1021/bi049677f

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the ADAM (a disintegrin and metalloproteinase) family of proteolytic enzymes are implicated in the processing of many single transmembrane-bound proteins ranging from cell surface receptors to growth factors and cytokines. Because of the biological significance of these processing events, a recurring theme in studying ADAM biology is that they are involved in physiological processes that can go awry and lead to disease states. This review provides a comprehensive look at ADAM family members and their role in pathology and provides a pathway for determining whether an enzyme is a physiological convertase for a given protein. In addition, ADAMs are discussed as potential therapeutic targets.

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收藏

页码：7227 / 7235

页数：9

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