Drosophila neuroblast asymmetric cell division:: Recent advances and implications for stem cell biology

被引：129

作者：

Yu, Fengwei

Kuo, Chay T.

Jan, Yuh Nung

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Physiol Biochem & Biophys, San Francisco, CA 94143 USA

[3] Natl Univ Singapore, Dept Biol Sci, Singapore 117604, Singapore

[4] Natl Univ Singapore, Temasek Life Sci Lab, Singapore 117604, Singapore

来源：

NEURON | 2006年 / 51卷 / 01期

关键词：

D O I：

10.1016/j.neuron.2006.06.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Asymmetric cell division is an evolutionarily conserved mechanism widely used to generate cellular diversity during development. Drosophila neuroblasts have been a useful model system for studying the molecular mechanisms of asymmetric cell division. In this minireview, we focus on recent progress in understanding the role of heterotrimeric G proteins and their regulators in asymmetric spindle geometry, as well as the role of an Inscuteable-independent microtubule pathway in asymmetric localization of proteins in neuroblasts. We also discuss issues of progenitor proliferation and differentiation associated with asymmetric cell division and their broader implications for stem cell biology.

引用

收藏

页码：13 / 20

页数：8

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