Lymphocyte subset abnormalities in canine leishmaniasis

被引：49

作者：

Bourdoiseau, G

Bonnefont, C

Magnol, JP

SaintAndre, I

Chabanne, L

机构：

[1] ECOLE NATL VET LYON, DEPT PATHOL & CLIN CARNIVORES DOMEST, UNITE DERMATOL, F-69280 MARCY LETOILE, FRANCE

[2] ECOLE NATL VET LYON, DEPT PATHOL & CLIN CARNIVORES DOMEST, LAB IMMUNOPATHOL, F-69280 MARCY LETOILE, FRANCE

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1997年 / 56卷 / 3-4期

关键词：

Leishmania infantum; dogs; lymphocyte; CD;

D O I：

10.1016/S0165-2427(96)05768-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Peripheral blood lymphocyte subpopulations were studied in 42 Leishmania infantum-infected dogs using flow cytometry. Twenty-two healthy dogs were used as a control group. Analysis of the B-cell populations showed a reduction in the number of CD21 + cells in all the infected dogs. On the other hand, the disease was found to be associated with a striking decrease in the number of CD21 + cells and of T-lymphocyte CD4 + cells in comparison with asymptomatic dogs and with healthy dogs. This study suggests that the dysimmunity which is observed with leishmaniasis may be linked to a reduced number of T-lymphocyte CD4 + cells. (C) 1997 Elsevier Science B.V.

引用

页码：345 / 351

页数：7

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