Asymmetric synthesis of cyclic α-amino phosphonates using masked oxo sulfinimines (N-sulfinyl imines)

被引：38

作者：

Davis, FA ^{[1
]}

Lee, SH ^{[1
]}

Xu, H ^{[1
]}

机构：

[1] Temple Univ, Dept Chem, Philadelphia, PA 19122 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 11期

关键词：

D O I：

10.1021/jo040127x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Five-, six-, and seven-membered cyclic alpha-amino phosphonates, amino acid surrogates, are prepared in enantiomerically pure form via the highly diastereomeric addition of metal phosphonates to masked oxo sulfinimines. Hydrolysis of the resulting masked oxo alpha-amino phosphonates followed by reduction of the intermediate cyclic imino phosphonates affords the title compounds in good yield.

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页码：3774 / 3781

页数：8

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