Trafficking of receptor tyrosine kinases to the nucleus

被引：99

作者：

Carpenter, Graham ^{[1
]}

Liao, Hong-Jun ^{[1
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Biochem, Nashville, TN 37232 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2009年 / 315卷 / 09期

关键词：

ErbB receptors; EGF receptor; Receptor tyrosine kinase; Nucleus; Trafficking; REGULATED INTRAMEMBRANE PROTEOLYSIS; P75 NEUROTROPHIN RECEPTOR; GAMMA-SECRETASE CLEAVAGE; EPIDERMAL-GROWTH-FACTOR; INTRACELLULAR DOMAIN 4ICD; AMYLOID PRECURSOR PROTEIN; MAMMARY EPITHELIAL-CELLS; GATED SODIUM-CHANNELS; C-TERMINAL FRAGMENT; PRESENILIN/GAMMA-SECRETASE;

D O I：

10.1016/j.yexcr.2008.09.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

It has been known for at least 20 years that growth factors induce the internalization of cognate receptor tyrosine kinases (RTKs). The internalized receptors are then sorted to lysosomes or recycled to the cell surface. More recently, data have been published to indicate other intracellular destinations for the internalized RTKs. These include the nucleus, mitochondria, and cytoplasm. Also, it is recognized that trafficking to these novel destinations involves new biochemical mechanisms, such as proteolytic processing or interaction with translocons, and that these trafficking events have a function in signal transduction, implicating the receptor itself as a signaling element between the cell surface and the nucleus. (C) 2008 Elsevier Inc. All rights reserved.

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页码：1556 / 1566

页数：11

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