Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones

被引：38

作者：

Koohang, Ali ^{[1
]}

Majewski, Nathan D. ^{[1
]}

Szotek, Erika L. ^{[1
]}

Mar, Aye Aye ^{[1
]}

Eiznhamer, David A. ^{[1
]}

Flavin, Michael T. ^{[1
]}

Xu, Ze-Qi ^{[1
]}

机构：

[1] Adv Life Sci Inc, Res & Dev, Woodridge, IL 60517 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 08期

关键词：

2-Cyano-28-hydroxy-lup-1-en-3-one; Triterpenoid; Betulinic acid; Betulin; Cytotoxicity; BETULINIC ACID-DERIVATIVES; ACTIVATED-RECEPTOR-GAMMA; CANCER; TRITERPENOIDS; APOPTOSIS; PREVENTION; PATHWAY; ANALOGS; AGENTS; COLON;

D O I：

10.1016/j.bmcl.2009.02.107

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

New A-ring modified betulin and dihydrobetulin derivatives possessing the 2-cyano-1-en-3-one moiety were prepared and tested for cytotoxicity in seven cancer cell lines. The most active agent 9a synthesized in this account was further demonstrated to induce apoptosis and to activate caspases in malignant melanoma cells. (C) 2009 Elsevier Ltd. All rights reserved.

引用

收藏

页码：2168 / 2171

页数：4

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