FAST CARS: Engineering a laser spectroscopic technique for rapid identification of bacterial spores

被引:201
作者
Scully, MO [1 ]
Kattawar, GW
Lucht, RP
Opatrny, T
Pilloff, H
Rebane, A
Sokolov, AV
Zubairy, MS
机构
[1] Texas A&M Univ, Inst Quantum Studies, Dept Phys, College Stn, TX 77843 USA
[2] Texas A&M Univ, Dept Elect Engn, College Stn, TX 77843 USA
[3] Texas A&M Univ, Dept Engn Mech, College Stn, TX 77843 USA
[4] Max Planck Inst Quantum Opt, D-85748 Garching, Germany
[5] Palacky Univ, Dept Theoret Phys, CZ-77146 Olomouc, Czech Republic
[6] Montana State Univ, Dept Phys, Bozeman, MT 59715 USA
[7] Quaid I Azam Univ, Dept Elect, Islamabad 45320, Pakistan
关键词
D O I
10.1073/pnas.172290899
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Airborne contaminants, e.g., bacterial spores, are usually analyzed by time-consuming microscopic, chemical, and biological assays. Current research into real-time laser spectroscopic detectors of such contaminants is based on e.g., resonance fluorescence. The present approach derives from recent experiments in which atoms and molecules are prepared by one (or more) coherent laser(s) and probed by another set of lasers. However, generating and using maximally coherent oscillation in macromolecules having an enormous number of degrees of freedom is challenging. In particular, the short dephasing times and rapid internal conversion rates are major obstacles. However, adiabatic fast passage techniques and the ability to generate combs of phase-coherent femtosecond pulses provide tools for the generation and utilization of maximal quantum coherence in large molecules and biopolymers. We call this technique FAST CARS (femtosecond adaptive spectroscopic techniques for coherent anti-Stokes Raman spectroscopy), and the present article proposes and analyses ways in which it could be used to rapidly identify preselected molecules in real time.
引用
收藏
页码:10994 / 11001
页数:8
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