Viral avoidance and exploitation of the ubiquitin system

被引：183

作者：

Randow, Felix ^{[1
]}

Lehner, Paul J. ^{[2
]}

机构：

[1] MRC, Mol Biol Lab, Div Prot & Nucle Acid Chem, Cambridge CB2 0QH, England

[2] Univ Cambridge, Addenbrookes Hosp, Cambridge Inst Med Res, Dept Med, Cambridge CB2 0XY, England

来源：

NATURE CELL BIOLOGY | 2009年 / 11卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

MHC CLASS-I; HERPES-SIMPLEX-VIRUS; COMPLEX CLASS-I; REGULATORY PROTEIN ICP0; HUMAN CYTOMEGALOVIRUS; MEMBRANE-PROTEIN; E3; LIGASE; ENDOPLASMIC-RETICULUM; DOWN-REGULATION; CELL-SURFACE;

D O I：

10.1038/ncb0509-527

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The versatility of ubiquitin in regulating protein function and cell behaviour through post-translational protein modification makes it a particularly attractive target for viruses. Here we review how viruses manipulate the ubiquitin system to favour their propagation by redirecting cellular ubiquitin enzymes or encoding their own ubiquitin components to enable replication, egress and immune evasion. These studies not only reveal the many cellular processes requiring ubiquitin but also illustrate how viruses usurp their host cells.

引用

页码：527 / U35

页数：11

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