Gene therapy strategies for colon cancer

被引：35

作者：

Chung-Faye, GA ^{[1
]}

Kerr, DJ ^{[1
]}

Young, LS ^{[1
]}

Searle, PF ^{[1
]}

机构：

[1] Univ Birmingham, CRC, Inst Canc Studies, Birmingham B15 2TA, W Midlands, England

来源：

MOLECULAR MEDICINE TODAY | 2000年 / 6卷 / 02期

关键词：

D O I：

10.1016/S1357-4310(99)01598-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Colorectal cancer is the second most common cause of cancer mortality in Western countries. Gene therapy represents a novel approach to the treatment of colorectal cancer, and this review addresses the current strategies and ongoing clinical trials, including gene correction, immunomodulatory approaches and virus-directed enzyme-prodrug systems. Although the pre-clinical results for these strategies have been encouraging, clinical trials have not yet reflected these data. However, gene therapy for colorectal cancer is still in the early stages of development, and its potential, particularly in combination with conventional cancer therapies, warrants further investigation.

引用

页码：82 / 87

页数：8

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