Selective vulnerability in the developing central nervous system

被引:215
作者
McQuillen, PS
Ferriero, DM
机构
[1] Univ Calif San Francisco, Dept Pediat, Ctr Med, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Neurol, Ctr Med, San Francisco, CA 94143 USA
关键词
D O I
10.1016/j.pediatrneurol.2003.10.001
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Selective patterns of cerebral injury are observed after a variety of insults at different ages during development. Distinct populations of cells demonstrate selective vulnerability during these specific developmental stages, which may account for the observed patterns of injury. We review the evidence that injury to preoligodendrocytes and subplate neurons contributes to periventricular white matter injury in preterm infants, whereas thalamic neuronal cell vulnerability and neuronal nitric oxide synthase-expressing striatal interneurons resistance result in deep gray nuclei damage in the term infant. The unique roles of particular mechanisms including oxidative stress, glutamatergic neurotransmission, and programmed cell death are discussed in the context of this selective vulnerability. (C) 2004 by Elsevier Inc. All rights reserved.
引用
收藏
页码:227 / 235
页数:9
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