Specific Therapeutic Schemes of Omeprazole Affect the Orientation of Helicobacter pylori

被引：5

作者：

Azevedo-Vethacke, Marina ^{[1
]}

Garten, Desiree ^{[1
]}

Groll, Claudia ^{[1
]}

Schreiber, Soeren ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Inst Physiol, D-44801 Bochum, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 08期

关键词：

SEQUENTIAL THERAPY; GASTRIC MUCUS; IN-VIVO; INFECTION; ERADICATION; CLARITHROMYCIN; AMOXICILLIN; CHEMOTAXIS; CANCER; ULCER;

D O I：

10.1128/AAC.00158-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Until now, it has been unclear how proton pump inhibitors (PPIs) support Helicobacter pylori therapy. We tested whether the PPI omeprazole acts on the spatial orientation of H. pylori in the gastric mucus of infected Mongolian gerbils. Following repetitive PPI administration once daily but not following single doses or administration every 8 h, the bacterial spatial distribution changed, indicating a loss of orientation. Therefore, the therapeutic scheme of PPI administration may affect efficiency of treatment.

引用

页码：3511 / 3514

页数：4

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