Amphetamine-induced locomotor stereotypy in rats is reduced by a D-1 but not a D-2 antagonist

被引：23

作者：

Fritts, ME

Mueller, K

Morris, L

机构：

[1] Department of Psychology, Texas Christian University, Fort Worth

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1997年 / 58卷 / 04期

关键词：

amphetamine; stereotypy; D-1 and D-2 antagonists;

D O I：

10.1016/S0091-3057(97)00308-0

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Amphetamine produces locomotor stereotypy (repetitive routes of locomotion) in an open field. In this research we tested the ability of the D-1 antagonist SKF 83566 and the D-2 antagonist sulpiride to block the locomotor stereotypy produced by 2 mg/kg amphetamine. SKF 83566 decreased amphetamine-induced locomotor stereotypy; sulpiride had no consistent effect on amphetamine-induced locomotor stereotypy. There was no evidence that either antagonist potentiated the effect of the other. (C) 1997 Elsevier Science Inc.

引用

页码：1015 / 1019

页数：5

共 16 条

[1]

[Anonymous], BMDP STATISTICAL SOF

[2] OBLIGATORY D-1 D-2 RECEPTOR INTERACTION IN THE GENERATION OF DOPAMINE AGONIST RELATED BEHAVIORS [J].