Behavioral symptoms in mild cognitive impairment

被引：224

作者：

Feldman, H

Scheltens, P

Scarpini, E

Hermann, N

Mesenbrink, P

Mancione, L

Tekin, S

Lane, R

Ferris, S

机构：

[1] Univ British Columbia, Vancouver Hosp & Hlth Sci Ctr, Div Neurol, Vancouver, BC, Canada

[2] Vrije Univ Amsterdam, Med Ctr, Dept Neurol, Alzheimer Ctr, Amsterdam, Netherlands

[3] Univ Milan, IRCCS Maggiore Hosp, Dept Neurol, I-20122 Milan, Italy

[4] Univ Toronto, Div Geriatr Psychiat, Toronto, ON, Canada

[5] Novartis Pharmaceut Corp, E Hanover, NJ USA

[6] NYU, Med Ctr, Ctr Aging, New York, NY USA

来源：

NEUROLOGY | 2004年 / 62卷 / 07期

关键词：

D O I：

10.1212/01.WNL.0000118301.92105.EE

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors investigated neuropsychiatric symptoms in mild cognitive impairment (MCI) from baseline data of the Investigation in the Delay to Diagnosis of AD with Exelon (InDDEx) study (n=1,010). Neuropsychiatric symptoms were reported in 59% of subjects (Neuropsychiatric Inventory [NPI]). NPI+ subjects had significantly greater impairment on global, cognitive, and functional scores than NPI- subjects. The presence of neuropsychiatric symptoms appears to be a marker of MCI severity.

引用

收藏

页码：1199 / 1201

页数：3

相关论文

共 9 条

[1]

The evolution of psychiatric symptoms in Alzheimer's disease: A natural history study [J].

Jost, BC ;

Grossberg, GT .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1996, 44 (09) :1078-1081

[2]

Neuropsychological prediction of decline to dementia in nondemented elderly [J].

Kluger, A ;

Ferris, SH ;

Golomb, J ;

Mittelman, MS ;

Reisberg, B .

JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY, 1999, 12 (04) :168-179

[3]

Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment - Results from the Cardiovascular Health Study [J].

Lyketsos, CG ;

Lopez, O ;

Jones, B ;

Fitzpatrick, AL ;

Breitner, J ;

DeKosky, S .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (12) :1475-1483

[4]

The spectrum of behavioral changes in Alzheimer's disease [J].

Mega, MS ;

Cummings, JL ;

Fiorello, T ;

Gornbein, J .

NEUROLOGY, 1996, 46 (01) :130-135

[5]

THE CLINICAL DEMENTIA RATING (CDR) - CURRENT VERSION AND SCORING RULES [J].

MORRIS, JC .

NEUROLOGY, 1993, 43 (11) :2412-2414

[6]

Current concepts in mild cognitive impairment [J].

Petersen, RC ;

Doody, R ;

Kurz, A ;

Mohs, RC ;

Morris, JC ;

Rabins, PV ;

Ritchie, K ;

Rossor, M ;

Thal, L ;

Winblad, B .

ARCHIVES OF NEUROLOGY, 2001, 58 (12) :1985-1992

[7]

Mild cognitive impairment - Clinical characterization and outcome [J].

Petersen, RC ;

Smith, GE ;

Waring, SC ;

Ivnik, RJ ;

Tangalos, EG ;

Kokmen, E .

ARCHIVES OF NEUROLOGY, 1999, 56 (03) :303-308

[8]

Cognitive impairment with no dementia (CIND): Longitudinal studies, the findings, and the issues [J].

Tuokko, H ;

Frerichs, RJ .

CLINICAL NEUROPSYCHOLOGIST, 2000, 14 (04) :504-525

[9]

Depressive symptoms, cognitive decline, and risk of AD in older persons [J].

Wilson, RS ;

Barnes, LL ;

de Leon, CFM ;

Aggarwal, NT ;

Schneider, JS ;

Bach, J ;

Pilat, J ;

Beckett, LA ;

Arnold, SE ;

Evans, DA ;

Bennett, DA .

NEUROLOGY, 2002, 59 (03) :364-370