MTHFR 677TT genotype increases the risk for cervical artery dissections

被引：20

作者：

Kloss, M. ^{[1
]}

Wiest, T. ^{[1
]}

Hyrenbach, S. ^{[1
]}

Werner, I. ^{[1
]}

Arnold, M-L ^{[1
]}

Lichy, C. ^{[1
]}

Grond-Ginsbach, C. ^{[1
]}

机构：

[1] Heidelberg Univ, Dept Neurol, D-69120 Heidelberg, Germany

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2006年 / 77卷 / 08期

关键词：

D O I：

10.1136/jnnp.2006.089730

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The methylene tetrahydrofolate reductase (MTHFR) C677T polymorphism was studied in 174 German patients with cervical artery dissection (CAD). The results were compared with published data on 927 healthy German controls. In the series of patients, the frequency of T alleles and of TT carriers was slightly higher (13.8%) than among the healthy controls (10.6%). In patients with multiple dissections (n = 50), the proportion of TT carriers (18%) was found to be even higher and correlated with the number of events. The MTHFR C677T polymorphism was suggested to modify the risk for CAD.

引用

页码：951 / 952

页数：2

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