TNF and MAP kinase signalling pathways

被引：747

作者：

Sabio, Guadalupe ^{[1
]}

Davis, Roger J. ^{[2
,3
]}

机构：

[1] Fdn Ctr Nacl Invest Cardiovasc Carlos III, Dept Vasc Biol & Inflammat, Madrid 28029, Spain

[2] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[3] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

来源：

SEMINARS IN IMMUNOLOGY | 2014年 / 26卷 / 03期

关键词：

TNF; MAP kinase; ERK; JNK; p38 MAP kinase; TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; ACTIVATED PROTEIN-KINASE; STRESS-INDUCED PHOSPHORYLATION; JUN NH2-TERMINAL KINASE; MESSENGER-RNA STABILITY; FACTOR-ALPHA PROMOTER; AU-RICH ELEMENTS; C-JUN; P38; MAPK;

D O I：

10.1016/j.smim.2014.02.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The binding of tumour necrosis factor alpha (TNF alpha) to cell surface receptors engages multiple signal transduction pathways, including three groups of mitogen-activated protein (MAP) kinases: extracellular-signal-regulated kinases (ERKs); the cJun NH2-terminal kinases (JNKs); and the p38 MAP kinases. These MAP kinase signalling pathways induce a secondary response by increasing the expression of several inflammatory cytokines (including TNF alpha) that contribute to the biological activity of TNF alpha. MAP kinases therefore function both upstream and down-stream of signalling by TNFa receptors. Here we review mechanisms that mediate these actions of MAP kinases during the response to TNF alpha. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：237 / 245

页数：9

共 127 条

[1]

Cell type-specific function of TAK1 in innate immune signaling [J].

Ajibade, Adebusola A. ;

Wang, Helen Y. ;

Wang, Rong-Fu .

TRENDS IN IMMUNOLOGY, 2013, 34 (07) :307-316

[2]

Ajibade AA, 2012, IMMUNITY, V36, P43, DOI 10.1016/j.immuni.2011.12.010

[3]

Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IκB phosphorylation and NF-κB activation [J].

Alpert, D ;

Schwenger, P ;

Han, JH ;

Vilcek, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (32) :22176-22183

[4]

Mitogen-activated protein kinases in innate immunity [J].

Arthur, J. Simon C. ;

Ley, Steven C. .

NATURE REVIEWS IMMUNOLOGY, 2013, 13 (09) :679-692

[5]

Generation and characterization of p38β (MAPK11) gene-targeted mice [J].

Beardmore, VA ;

Hinton, HJ ;

Eftychi, C ;

Apostolaki, M ;

Armaka, M ;

Darragh, J ;

McIlrath, J ;

Carr, JM ;

Armit, LJ ;

Clacher, C ;

Malone, L ;

Kollias, G ;

Arthur, JSC .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (23) :10454-10464

[6]

Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105 [J].

Beinke, S ;

Robinson, MJ ;

Hugunin, M ;

Ley, SC .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (21) :9658-9667

[7]

Affinity purification of ARE-binding proteins identifies poly(A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization [J].

Bollig, F ;

Winzen, R ;

Gaestel, M ;

Kostka, S ;

Resch, K ;

Holtmann, H .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (03) :665-670

[8]

Vitamin C inhibits NF-κB activation by TNF via the activation of p38 mitogen-activated protein kinase [J].

Bowie, AG ;

O'Neill, LAJ .

JOURNAL OF IMMUNOLOGY, 2000, 165 (12) :7180-7188

[9]

Mechanism of p38 MAP kinase activation in vivo [J].

Brancho, D ;

Tanaka, N ;

Jaeschke, A ;

Ventura, JJ ;

Kelkar, N ;

Tanaka, Y ;

Kyuuma, M ;

Takeshita, T ;

Flavell, RA ;

Davis, RJ .

GENES & DEVELOPMENT, 2003, 17 (16) :1969-1978

[10]

The Mnks are novel components in the control of TNFα biosynthesis and phosphorylate and regulate hnRNP A1 [J].

Buxadé, M ;

Parra, JL ;

Rousseau, S ;

Shpiro, N ;

Marquez, R ;

Morrice, N ;

Bain, J ;

Espel, E ;

Proud, CG .

IMMUNITY, 2005, 23 (02) :177-189

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