Summation theorems for flux and concentration control coefficients of dynamic systems

被引：12

作者：

Conradie, R.

Westerhoff, H. V.

Rohwer, J. M.

Hofmeyr, J. -H. S.

Snoep, J. L.

机构：

[1] Univ Stellenbosch, Dept Biochem, ZA-7602 Matieland, South Africa

[2] Vrije Univ Amsterdam, NL-1081 HV Amsterdam, Netherlands

[3] Univ Manchester, Sch Chem, Manchester Ctr Integrat Syst Biol, Manchester M60 1QD, Lancs, England

来源：

IEE PROCEEDINGS SYSTEMS BIOLOGY | 2006年 / 153卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1049/ip-syb:20060024

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Metabolic control analysis (MCA) was developed to quantify how system variables are affected by parameter variations in a system. In addition, MCA can express the global properties of a system in terms of the individual catalytic steps, using connectivity and summation theorems to link the control coefficients to the elasticity coefficients. MCA was originally developed for steady-state analysis and not all summation theorems have been derived for dynamic systems. A method to determine time-dependent flux and concentration control coefficients for dynamic systems by expressing the time domain as a function of percentage progression through any arbitrary fixed interval of time is reported. Time-dependent flux and concentration control coefficients of dynamic systems, provided that they are evaluated in this novel way, obey the same summation theorems as steady-state flux and concentration control coefficients, respectively.

引用

页码：314 / 317

页数：4

共 17 条

[1]

ACERENZA L, 1990, NATO ADV SCI I A-LIF, V190, P297

[2]

CONTROL ANALYSIS OF TIME-DEPENDENT METABOLIC SYSTEMS [J].