Relating axonal injury to functional recovery in MS

被引：132

作者：

Reddy, H

Narayanan, S

Matthews, PM

Hoge, RD

Pike, GB

Duquette, P

Antel, J

Arnold, DL

机构：

[1] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

[2] Univ Oxford, Dept Clin Neurol, Ctr Funct Magnet Resonance Imaging Brain, Oxford OX1 2JD, England

[3] Univ Montreal, Hop Notre Dame de Bon Secours, Dept Clin Neurol, Montreal, PQ H3C 3J7, Canada

来源：

NEUROLOGY | 2000年 / 54卷 / 01期

关键词：

axonal injury; MS; functional MRI; plasticity; spectroscopy;

D O I：

10.1212/WNL.54.1.236

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A patient was followed after the new onset of hemiparesis from relapse of MS with serial MR spectroscopy and functional MRI. The association of clinical improvement with recovery of N-acetylaspartate, a marker of neuronal integrity, and progressive reduction of abnormally large functional MRI cortical activation with movement demonstrates that dynamic reorganization of the motor cortex accompanies remission of MS.

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页码：236 / 239

页数：4

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