Adipocytes recognize and degrade oxidized low density lipoprotein through CD36

被引：58

作者：

Kuniyasu, A ^{[1
]}

Hayashi, S ^{[1
]}

Nakayama, H ^{[1
]}

机构：

[1] Kumamoto Univ, Fac Pharmaceut Sci, Dept Biofunct Chem, Kumamoto 8620973, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2002年 / 295卷 / 02期

关键词：

CD36; scavenger receptor; adipocytes; 3T3-L1; cells; oxidized LDL; endocytic uptake; lysosomal degradation;

D O I：

10.1016/S0006-291X(02)00666-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD36 expressed on adipocytes is thought to function as a fatty acid transporter (FAT). Here we report that adipocytes can endocytose and lysosomally degrade OxLDL, mainly mediated by CD36. Mouse 3T3-L1 preadipocytes showed marked increase in uptake and degradation of I-125-OxLDL during their differentiation to adipocytes. RT-PCR and immunoblot analysis indicated that expression of CD36 but not of scavenger receptor class A or macrosialin is required for the increase in uptake and degradation of I-125-OxLDL in 3T3-L1 cells. An anti-CD36 antibody inhibited both uptake and degradation activities of I-125-OxLDL up to 60%. These results strongly suggest that adipocytes may function as phagocytes like macrophages and that CD36 plays a novel role in adipose tissues. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：319 / 323

页数：5

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