Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997

被引:39
作者
Engels, EA
Rosenberg, PS
Biggar, RJ
机构
[1] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20822 USA
[2] NCI, Biostat Branch, Div Canc Epidemiol & Genet, Rockville, MD 20822 USA
关键词
D O I
10.1086/315146
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for tester and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 tester cases were identified (average yearly incidence, 2.5%). Prior tester episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95), Among hemophiliacs, children and adolescents had the highest tester risk, and tester risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93), These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella tester virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm(3) but increased steeply below this level. During the 14 years of follow-up, tester incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.
引用
收藏
页码:1784 / 1789
页数:6
相关论文
共 29 条
[1]  
Aldeen T, 1998, AIDS, V12, P1719
[2]   Herpes zoster and progression to AIDS in a cohort of individuals who seroconverted to human immunodeficiency virus [J].
Alliegro, MB ;
Dorrucci, M ;
Pezzotti, P ;
Rezza, G ;
Sinicco, A ;
Barbanera, M ;
Castelli, F ;
Tarantini, G ;
Petrucci, A ;
Lepri, AC ;
Angarano, G ;
Buccoliero, G ;
Zaccarelli, M ;
Salassa, B ;
Tomasoni, L ;
Ricchi, E ;
Gafa, S ;
Viale, P ;
Ortona, L ;
Tirelli, U ;
Canessa, A ;
Pristera, R ;
Lazzarin, A ;
Aiuti, F .
CLINICAL INFECTIOUS DISEASES, 1996, 23 (05) :990-995
[3]   IMMUNOLOGICAL EVIDENCE OF REINFECTION WITH VARICELLA-ZOSTER VIRUS [J].
ARVIN, AM ;
KOROPCHAK, CM ;
WITTEK, AE .
JOURNAL OF INFECTIOUS DISEASES, 1983, 148 (02) :200-205
[4]   HERPES-ZOSTER AND HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION [J].
BUCHBINDER, SP ;
KATZ, MH ;
HESSOL, NA ;
LIU, JY ;
OMALLEY, PM ;
UNDERWOOD, R ;
HOLMBERG, SD .
JOURNAL OF INFECTIOUS DISEASES, 1992, 166 (05) :1153-1156
[5]   Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection [J].
Coombs, RW ;
Welles, SL ;
Hooper, C ;
Reichelderfer, PS ;
DAquila, RT ;
Japour, AJ ;
Johnson, VA ;
Kuritzkes, DR ;
Richman, DD ;
Kwok, S ;
Todd, J ;
Jackson, JB ;
DeGruttola, V ;
Crumpacker, CS ;
Kahn, J .
JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (04) :704-712
[6]  
Dawson-Saunders B., 1994, Basic and clinical biostatistics, V2
[7]   THE INCIDENCE OF HERPES-ZOSTER [J].
DONAHUE, JG ;
CHOO, PW ;
MANSON, JE ;
PLATT, R .
ARCHIVES OF INTERNAL MEDICINE, 1995, 155 (15) :1605-1609
[8]   PREVALENCE OF ANTIBODIES TO HUMAN HERPESVIRUSES AND HEPATITIS-B VIRUS IN PATIENTS AT DIFFERENT STAGES OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION [J].
ENZENSBERGER, R ;
BRAUN, W ;
JULY, C ;
HELM, EB ;
DOERR, HW .
INFECTION, 1991, 19 (03) :140-145
[9]   The incidence and spectrum of AIDS-defining illnesses in persons treated with antiretroviral drugs [J].
Forrest, DM ;
Seminari, E ;
Hogg, RS ;
Yip, B ;
Raboud, J ;
Lawson, L ;
Phillips, P ;
Schechter, MT ;
O'Shaughnessy, MV ;
Montaner, JSG .
CLINICAL INFECTIOUS DISEASES, 1998, 27 (06) :1379-1385
[10]   Varicella-zoster virus infection in children with underlying human immunodeficiency virus infection [J].
Gershon, AA ;
Mervish, N ;
LaRussa, P ;
Steinberg, S ;
Lo, SH ;
Hodes, D ;
Fikrig, S ;
Bonagura, V ;
Bakshi, S .
JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (06) :1496-1500