Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies

被引：200

作者：

Deo, YM

Graziano, RF

Repp, R

vandeWinkel, JGJ

机构：

[1] UNIV ERLANGEN NURNBERG, DIV HEMATOL ONCOL, D-8520 ERLANGEN, GERMANY

[2] UNIV UTRECHT HOSP, DEPT IMMUNOL, NL-3508 GA UTRECHT, NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1997年 / 18卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(97)01007-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Fc receptors for IgG (Fc gamma Rs) can trigger the inflammatory, cytotoxic and hypersensitivity functions of immune effector cells. Activation or deactivation of effector cells via Fc gamma Rs can be exploited to develop novel therapies for cancer, infectious diseases and autoimmune disorders. Initial results of clinical trials for several Fc gamma R-directed immunotherapies show the potential promise of this approach.

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收藏

页码：127 / 135

页数：9

相关论文

共 57 条

[1]

TUMORS UNDERGOING REJECTION INDUCED BY MONOCLONAL-ANTIBODIES OF THE IGG2A ISOTYPE CONTAIN INCREASED NUMBERS OF MACROPHAGES ACTIVATED FOR A DISTINCTIVE FORM OF ANTIBODY-DEPENDENT CYTOLYSIS [J].

ADAMS, DO ;

HALL, T ;

STEPLEWSKI, Z ;

KOPROWSKI, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (11) :3506-3510

[2]

CYTOPLASMIC DOMAIN HETEROGENEITY AND FUNCTIONS OF IGG FC-RECEPTORS IN LYMPHOCYTES-B [J].

AMIGORENA, S ;

BONNEROT, C ;

DRAKE, JR ;

CHOQUET, D ;

HUNZIKER, W ;

GUILLET, JG ;

WEBSTER, P ;

SAUTES, C ;

MELLMAN, I ;

FRIDMAN, WH .

SCIENCE, 1992, 256 (5065) :1808-1812

[3]

Ball E D, 1992, J Hematother, V1, P85, DOI 10.1089/scd.1.1992.1.85

[4]

Phase II study of weekly intravenous recombinant humanized Anti-p185(HER2) monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast [J].

Baselga, J ;

Tripathy, D ;

Mendelsohn, J ;

Baughman, S ;

Benz, CC ;

Dantis, L ;

Sklarin, NT ;

Seidman, AD ;

Hudis, CA ;

Moore, J ;

Rosen, PP ;

Twaddell, T ;

Henderson, IC ;

Norton, L .

JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (03) :737-744

[5]

FACTORS INFLUENCING ANTIBODY-MEDIATED CYTO-TOXICITY DURING THE IMMUNOTHERAPY OF RAUSCHER-VIRUS-INDUCED MYELOID LEUKEMIC-CELLS [J].

BERENDS, D ;

VANDERKWAST, TH ;

DEBOTH, NJ ;

MULDER, PGH .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 1989, 28 (02) :123-130

[6]

BOROS P, 1993, J IMMUNOL, V150, P2018

[7]

IGM ANTI-FC-GAMMA-R AUTOANTIBODIES TRIGGER NEUTROPHIL DEGRANULATION [J].

BOROS, P ;

ODIN, JA ;

MURYOI, T ;

MASUR, SK ;

BONA, C ;

UNKELESS, JC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (06) :1473-1482

[8]

BUSSEL JB, 1991, BLOOD, V77, P1884

[9]

CARON PC, 1994, BLOOD, V83, P1760

[10]

TREATMENT OF REFRACTORY IMMUNE THROMBOCYTOPENIC PURPURA WITH AN ANTI-FC-GAMMA-RECEPTOR ANTIBODY [J].

CLARKSON, SB ;

BUSSEL, JB ;

KIMBERLY, RP ;

VALINSKY, JE ;

NACHMAN, RL ;

UNKELESS, JC .

NEW ENGLAND JOURNAL OF MEDICINE, 1986, 314 (19) :1236-1239

← 1 2 3 4 5 6 →