Vitamin D in diabetes mellitus - a new field of knowledge poised for D-velopment

被引：21

作者：

Alfonso, B.

Liao, E.

Busta, A.

Poretsky, L. ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Div Endocrinol & Metab, New York, NY 10003 USA

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2009年 / 25卷 / 05期

关键词：

vitamin D; type 1 diabetes mellitus; type 2 diabetes mellitus; adult onset latent autoimmune diabetes (LADA); BETA-CELL FUNCTION; SUSCEPTIBILITY; ADULT; RISK; D-3;

D O I：

10.1002/dmrr.927

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

This commentary reviews the current state of knowledge regarding the role of vitamin D in the pathogenesis of diabetes mellitus. In type 1 diabetes mellitus or in adult onset latent autoimmune diabetes (LADA), vitamin D exhibits immunomodulatory actions, influencing the activity of lymphocytes and interleukins. In type 2 diabetes mellitus vitamin D appears to act through different mechanisms, affecting insulin secretion and insulin sensitivity through its effects on the beta cells, mediators of inflammation and parathyroid hormone. Much work remains to be done in this new field of knowledge before the role of vitamin D in the pathogenesis of diabetes mellitus is completely understood. Copyright (c) 2009 John Wiley & Sons, Ltd.

引用

页码：417 / 419

页数：3

共 21 条

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[2]

Cell death mediators in autoimmune diabetes - No shortage of suspects [J].