Changes in the Length of the Neuraminidase Stalk Region Impact H7N9 Virulence in Mice

被引：36

作者：

Bi, Yuhai ^{[1
,2
,5
]}

Xiao, Haixia ^{[3
,5
]}

Chen, Quanjiao ^{[4
,5
]}

Wu, Yan

Fu, Lifeng

Quan, Chuansong ^{[6
]}

Wong, Gary

Liu, Jun ^{[5
,6
]}

Haywood, Joel ^{[1
]}

Liu, Yingxia ^{[2
]}

Zhou, Boping ^{[2
]}

Yan, Jinghua ^{[1
]}

Liu, Wenjun ^{[1
,5
]}

Gao, George F. ^{[1
,2
,3
,5
,6
,7
,8
]}

机构：

[1] Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China

[2] Shenzhen Third Peoples Hosp, Shenzhen Key Lab Pathogen & Immun, Shenzhen, Peoples R China

[3] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Lab Prot Engn & Vaccines, Tianjin, Peoples R China

[4] Chinese Acad Sci, Wuhan Inst Virol, CAS Key Lab Special Pathogens & Biosafety, Beijing 100864, Hubei, Peoples R China

[5] Chinese Acad Sci, Ctr Influenza Res & Early Warning CASCIRE, Beijing, Peoples R China

[6] Chinese Ctr Dis Control & Prevent China CDC, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China

[7] Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Peoples R China

[8] Chinese Acad Sci, RNIH, Beijing Inst Life Sci, Beijing, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 04期

基金：

中国国家自然科学基金;

关键词：

INFLUENZA-A VIRUS; HEMAGGLUTININ CLEAVAGE; FUNCTIONAL BALANCE; PATHOGENICITY; CHICKENS; TRANSMISSION; REPLICATION; EMERGENCE; FERRETS; HUMANS;

D O I：

10.1128/JVI.02553-15

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The neuraminidase stalk of the newly emerged H7N9 influenza virus possesses a 5-amino-acid deletion. This study focuses on characterizing the biological functions of H7N9 with varied neuraminidase stalk lengths. Results indicate that the 5-amino-acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to that of a virus with a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19-to 20-amino-acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 stalk length does.

引用

页码：2142 / 2149

页数：8

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