Cannabinoid CB1 receptor protein expression in the rat choroid plexus: a possible involvement of cannabinoids in the regulation of cerebrospinal fluid

被引：14

作者：

Ashton, JC ^{[1
]}

Appleton, I ^{[1
]}

Darlington, CL ^{[1
]}

Smith, PF ^{[1
]}

机构：

[1] Univ Otago Med Sch, Sch Med Sci, Dept Pharmacol & Toxicol, Dunedin, New Zealand

来源：

NEUROSCIENCE LETTERS | 2004年 / 364卷 / 01期

关键词：

cannabinoid CB1 receptor; choroid plexus; immunohistochemistry;

D O I：

10.1016/j.neulet.2004.04.016

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cannabinoid CB1 receptors in the brain are expressed on axon terminals presynaptic to neurons that express fatty acid amide hydrolase (FAAH). Postsynaptic FAAH catabolizes endocannabinoids which act as short-range transmitters. It has been previously shown that FAAH is also expressed in the epithelial cells of the choroid plexus. Using immunohistochemisty, we found that CB1 receptor protein is also expressed in choroid plexus epithelia. This is consistent with the hypothesis that FAAH in choroid plexus epithelial cells catabolizes endocannabinoids close to their site of action. Cannabinoids may then act directly on choroid plexus cells, and thereby contribute to the regulation of the composition of the CSF. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：40 / 42

页数：3

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