Diacylglycerol kinases

被引：90

作者：

Luo, B ^{[1
]}

Regier, DS ^{[1
]}

Prescott, SM ^{[1
]}

Topham, MK ^{[1
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

CELLULAR SIGNALLING | 2004年 / 16卷 / 09期

关键词：

diacylgtycerol kinases; diacylglycerol; phosphatidic acid; lipid signalling; phosphatidylinositol; nucleus; cytoskeleton;

D O I：

10.1016/j.cellsig.2004.03.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol kinases. By modulating the activity of these proteins, DGKs potentially affect a number of biological events including-but likely not limited to-cell growth, neuronal transmission, and cytoskeleton remodeling. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：983 / 989

页数：7

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